Ajsp Reviews and Report

In this issue of AJSP: Reviews & Reports,
Drs Bosse and Köbel share their thoughts in 2 separate articles on how they envision the future with the
added complexity of molecular information on top of standard anatomical pathology. Both agree on the
value of molecular information and certain basic principles (eg, the defining nature of key oncogenic alterations
such as POLE mutations or mismatch repair deficiency). However, they have different views of how
to integrate molecular subtype information with standard histomorphology: with one approach being more
integrated versus more stand-alone. Although standard histomorphology and molecular subtype strongly
correlate, sometimes they contradict each other. At this point, someone, either the pathologist or the oncologist,
has to adjudicate. This decision is not generalizable and is dependent on the context of the specific
histomorphology and the specific molecular result, and who would be better posed to make that decision
than a pathologist? Designation of an endometrial carcinoma to a specific category increasingly conveys
prognostic, predictive, and germline information; accurate and reproducible diagnosis is mandatory. Integration
of the traditional and molecular parameters is critical to ensure a relevant taxonomy of endometrial
pathology with the ultimate goal of improving the outcomes in women’s health.